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Local chromatin context regulates the genetic requirements of the heterochromatin spreading reaction

Heterochromatin spreading, the expansion of repressive chromatin structure from sequence-specific nucleation sites, is critical for stable gene silencing. Spreading re-establishes gene-poor constitutive heterochromatin across cell cycles but can also invade gene-rich euchromatin de novo to steer cel...

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Detalles Bibliográficos
Autores principales: Greenstein, R. A., Ng, Henry, Barrales, Ramon R., Tan, Catherine, Braun, Sigurd, Al-Sady, Bassem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154106/
https://www.ncbi.nlm.nih.gov/pubmed/35584134
http://dx.doi.org/10.1371/journal.pgen.1010201