Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release

Argonaute (Ago) proteins play a central role in post-transcriptional gene regulation through RNA interference (RNAi). Agos bind small RNAs (sRNAs) including small interfering RNAs (siRNAs) and microRNAs (miRNAs) to form the functional core of the RNA-induced silencing complex (RISC). The sRNA is use...

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Detalles Bibliográficos
Autores principales: Bibel, Brianna, Elkayam, Elad, Silletti, Steve, Komives, Elizabeth A, Joshua-Tor, Leemor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154749/
https://www.ncbi.nlm.nih.gov/pubmed/35638597
http://dx.doi.org/10.7554/eLife.76908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154749/
https://www.ncbi.nlm.nih.gov/pubmed/35638597
http://dx.doi.org/10.7554/eLife.76908

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