The proximity of the N- and C- termini of bovine knob domains enable engineering of target specificity into polypeptide chains

Cysteine-rich knob domains can be isolated from the ultralong heavy-chain complementarity-determining region (CDR) 3, which are unique to a subset of bovine antibodies, to create antibody fragments of ~4 kDa. Advantageously, the N- and C- termini of these small binding domains are in close proximity...

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Detalles Bibliográficos
Autores principales: Hawkins, Alice, Joyce, Callum, Brady, Kevin, Hold, Adam, Smith, Alan, Knight, Michael, Howard, Conor, van den Elsen, Jean, Lawson, Alastair D.G., Macpherson, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154775/
https://www.ncbi.nlm.nih.gov/pubmed/35634719
http://dx.doi.org/10.1080/19420862.2022.2076295

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154775/
https://www.ncbi.nlm.nih.gov/pubmed/35634719
http://dx.doi.org/10.1080/19420862.2022.2076295

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