Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A(2A)/A(2B) adenosine receptor antagonists

A series of novel dual A(2A)/A(2B) AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A(2A) AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or its open-ring bioisosteres. In addition,...

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Detalles Bibliográficos
Autores principales: Li, Zhi, Kou, Lijuan, Fu, Xinzhen, Xie, Zeping, Xu, Maolei, Guo, Lin, Lin, Tiantian, Gong, Shizhou, Zhang, Shumin, Liu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154793/
https://www.ncbi.nlm.nih.gov/pubmed/35616298
http://dx.doi.org/10.1080/14756366.2022.2077731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154793/
https://www.ncbi.nlm.nih.gov/pubmed/35616298
http://dx.doi.org/10.1080/14756366.2022.2077731

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