Triazoloquinoxalines-based DNA intercalators-Topo II inhibitors: design, synthesis, docking, ADMET and anti-proliferative evaluations

Sixteen [1, 2, 4]triazolo[4,3-a]quinoxalines as DNA intercalators-Topo II inhibitors have been prepared and their anticancer actions evaluated towards three cancer cell lines. The new compounds affected on high percentage of MCF-7. Derivatives 7e, 7c and 7b exhibited the highest anticancer activitie...

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Detalles Bibliográficos
Autores principales: Elwan, Alaa, Sakr, Helmy, El-Helby, Abdel-Ghany A., El-morsy, Ahmed, Abdelgawad, Mohamed A., Ghoneim, Mohammed M., El-Sherbiny, Mohamed, El-Adl, Khaled
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154796/
https://www.ncbi.nlm.nih.gov/pubmed/35635148
http://dx.doi.org/10.1080/14756366.2022.2080205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154796/
https://www.ncbi.nlm.nih.gov/pubmed/35635148
http://dx.doi.org/10.1080/14756366.2022.2080205

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