Cargando…

Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis

In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides. All compounds were assayed for human carbonic anhydrase (hCA) isoforms...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siwach, Kiran, Kumar, Amit, Panchal, Harish, Kumar, Rajiv, Bhardwaj, Jitender Kumar, Angeli, Andrea, Supuran, Claudiu T., Sharma, Pawan K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2022
Materias:	Research Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154810/ https://www.ncbi.nlm.nih.gov/pubmed/35616287 http://dx.doi.org/10.1080/14756366.2022.2077333

Ejemplares similares

Synthesis and biological evaluation of benzenesulphonamide-bearing 1,4,5-trisubstituted-1,2,3-triazoles possessing human carbonic anhydrase I, II, IV, and IX inhibitory activity
por: Kumar, Rajiv, et al.
Publicado: (2017)

Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases
por: Abdoli, Morteza, et al.
Publicado: (2023)

Bioorganometallic derivatives of 4-hydrazino-benzenesulphonamide as carbonic anhydrase inhibitors: synthesis, characterisation and biological evaluation
por: Brichet, Jeremie, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis
por: Thacker, Pavitra S., et al.
Publicado: (2021)

Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors
por: Swain, Baijayantimala, et al.
Publicado: (2019)

Design, Synthesis, and Biological Evaluation of 1,2,3-Triazole-linked triazino[5,6-b]indole-benzene sulfonamide Conjugates as Potent Carbonic Anhydrase I, II, IX, and XIII Inhibitors
por: Chinchilli, Krishna Kartheek, et al.
Publicado: (2020)

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2018)

Investigation on Hydrazonobenzenesulfonamides as Human Carbonic Anhydrase I, II, IX and XII Inhibitors
por: Moi, Davide, et al.
Publicado: (2022)

Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors
por: Berrino, Emanuela, et al.
Publicado: (2020)

Carbonic anhydrase IX as a novel candidate in liquid biopsy
por: Ozensoy Guler, Ozen, et al.
Publicado: (2019)

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
por: Gumus, Arzu, et al.
Publicado: (2022)

Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases
por: Distinto, Simona, et al.
Publicado: (2019)

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
por: McDonald, Paul C., et al.
Publicado: (2012)

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
por: Meleddu, Rita, et al.
Publicado: (2021)

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity
por: Moi, Davide, et al.
Publicado: (2022)

Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors
por: Astrain-Redin, Nora, et al.
Publicado: (2023)

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors
por: Güzel-Akdemir, Özlen, et al.
Publicado: (2018)

A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors
por: Alhameed, Rakia Abd, et al.
Publicado: (2020)

Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX
por: Zain-Alabdeen, Abdelrahman I., et al.
Publicado: (2022)

Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors
por: Onyılmaz, Mehmet, et al.
Publicado: (2022)

Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II
por: Ivanova, Jekaterīna, et al.
Publicado: (2023)

Carbonic Anhydrase IX Inhibitors as Candidates for Combination Therapy of Solid Tumors
por: Kalinin, Stanislav, et al.
Publicado: (2021)

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
por: Abdoli, Morteza, et al.
Publicado: (2017)

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
por: Angeli, Andrea, et al.
Publicado: (2023)

Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors
por: Zengin Kurt, Belma, et al.
Publicado: (2017)

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside
por: McDonald, Paul C., et al.
Publicado: (2022)

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII
por: Cau, Ylenia, et al.
Publicado: (2017)

Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action
por: Bragagni, Marco, et al.
Publicado: (2017)

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors
por: Akocak, Suleyman, et al.
Publicado: (2018)

Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Benzenesulphonamide inhibitors of the cytolytic protein perforin
por: Spicer, Julie A., et al.
Publicado: (2017)

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells
por: Koyuncu, Ismail, et al.
Publicado: (2019)

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII
por: Mahammad Ghouse, Shaik, et al.
Publicado: (2023)

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII
por: Mancuso, Francesca, et al.
Publicado: (2020)

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII
por: Buran, Kerem, et al.
Publicado: (2019)

Carbonic anhydrase inhibition with a series of novel benzenesulfonamide-triazole conjugates
por: El-Gazzar, Marwa G., et al.
Publicado: (2018)

Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates
por: Moeker, Janina, et al.
Publicado: (2014)

Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
por: Krasavin, Mikhail, et al.
Publicado: (2020)

Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors
por: Ramya, P. V. Sri, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ubq7mba4g5cfcof3d1kuogmkmv