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Systematic evaluation of computational tools to predict the effects of mutations on protein stability in the absence of experimental structures
Changes in protein sequence can have dramatic effects on how proteins fold, their stability and dynamics. Over the last 20 years, pioneering methods have been developed to try to estimate the effects of missense mutations on protein stability, leveraging growing availability of protein 3D structures...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9155634/ https://www.ncbi.nlm.nih.gov/pubmed/35189634 http://dx.doi.org/10.1093/bib/bbac025 |