Cardiac Mesenchymal Stem Cells Promote Fibrosis and Remodeling in Heart Failure: Role of PDGF Signaling

Heart failure (HF) is characterized by progressive fibrosis. Both fibroblasts and mesenchymal stem cells (MSCs) can differentiate into pro-fibrotic myofibroblasts. MSCs secrete and express platelet-derived growth factor (PDGF) and its receptors. We hypothesized that PDGF signaling in cardiac MSCs (c...

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Detalles Bibliográficos
Autores principales: Hamid, Tariq, Xu, Yuanyuan, Ismahil, Mohamed Ameen, Rokosh, Gregg, Jinno, Miki, Zhou, Guihua, Wang, Qiongxin, Prabhu, Sumanth D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Preclinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156441/
https://www.ncbi.nlm.nih.gov/pubmed/35663630
http://dx.doi.org/10.1016/j.jacbts.2022.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156441/
https://www.ncbi.nlm.nih.gov/pubmed/35663630
http://dx.doi.org/10.1016/j.jacbts.2022.01.004

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