Blood DNA methylation at TXNIP and glycemic changes in response to weight-loss diet interventions: the POUNDS Lost Trial

BACKGROUND: Thioredoxin Interacting Protein (TXNIP) functions as a master regulator for glucose homeostasis. Hypomethylation at the 5’-cytosine-phosphate-guanine-3’ (CpG) site cg19693031 of TXNIP has been consistently related to islet dysfunction, hyperglycemia, and type 2 diabetes. DNA methylation...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Shao, Xiaojian, Bazzano, Lydia A., Xue, Qiaochu, Kosewa, Boryana S., Grundberg, Elin, Shai, Iris, Bray, George A., Sacks, Frank M., Qi, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156542/
https://www.ncbi.nlm.nih.gov/pubmed/35165382
http://dx.doi.org/10.1038/s41366-022-01084-5

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