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Omega-3 fatty acid epoxides produced by PAF-AH2 in mast cells regulate pulmonary vascular remodeling

Pulmonary hypertension is a fatal rare disease that causes right heart failure by elevated pulmonary arterial resistance. There is an unmet medical need for the development of therapeutics focusing on the pulmonary vascular remodeling. Bioactive lipids produced by perivascular inflammatory cells mig...

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Detalles Bibliográficos
Autores principales: Moriyama, Hidenori, Endo, Jin, Kataoka, Masaharu, Shimanaka, Yuta, Kono, Nozomu, Sugiura, Yuki, Goto, Shinichi, Kitakata, Hiroki, Hiraide, Takahiro, Yoshida, Naohiro, Isobe, Sarasa, Yamamoto, Tsunehisa, Shirakawa, Kohsuke, Anzai, Atsushi, Katsumata, Yoshinori, Suematsu, Makoto, Kosaki, Kenjiro, Fukuda, Keiichi, Arai, Hiroyuki, Sano, Motoaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156667/
https://www.ncbi.nlm.nih.gov/pubmed/35641514
http://dx.doi.org/10.1038/s41467-022-30621-z