Cryo-EM structures of human A2ML1 elucidate the protease-inhibitory mechanism of the A2M family

A2ML1 is a monomeric protease inhibitor belonging to the A2M superfamily of protease inhibitors and complement factors. Here, we investigate the protease-inhibitory mechanism of human A2ML1 and determine the structures of its native and protease-cleaved conformations. The functional inhibitory unit...

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Detalles Bibliográficos
Autores principales: Nielsen, Nadia Sukusu, Zarantonello, Alessandra, Harwood, Seandean Lykke, Jensen, Kathrine Tejlgård, Kjøge, Katarzyna, Thøgersen, Ida B., Schauser, Leif, Karlsen, Jesper Lykkegaard, Andersen, Gregers R., Enghild, Jan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156758/
https://www.ncbi.nlm.nih.gov/pubmed/35641520
http://dx.doi.org/10.1038/s41467-022-30758-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156758/
https://www.ncbi.nlm.nih.gov/pubmed/35641520
http://dx.doi.org/10.1038/s41467-022-30758-x

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