Pharmacologic modulation of 5-fluorouracil by folinic acid and pyridoxine for treatment of patients with advanced breast carcinoma

High concentration pyridoxal 5’-phosphate, the cofactor of vitamin B6, potentiates cytotoxicity in cancer cells exposed to 5-fluorouracil (FUra) and folinic acid (FA). We studied the effect of high-dose pyridoxine on antitumor activity of regimens comprising FUra and FA in 27 advanced breast carcino...

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Detalles Bibliográficos
Autores principales: Machover, David, Goldschmidt, Emma, Almohamad, Wathek, Castagné, Vincent, Dairou, Julien, Desterke, Christophe, Gomez, Léa, Gaston-Mathé, Yann, Boucheix, Claude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156777/
https://www.ncbi.nlm.nih.gov/pubmed/35641554
http://dx.doi.org/10.1038/s41598-022-12998-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156777/
https://www.ncbi.nlm.nih.gov/pubmed/35641554
http://dx.doi.org/10.1038/s41598-022-12998-5

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