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BRD4 promotes resection and homology-directed repair of DNA double-strand breaks

Double-strand breaks (DSBs) are one of the most toxic forms of DNA damage and represent a major source of genomic instability. Members of the bromodomain and extra-terminal (BET) protein family are characterized as epigenetic readers that regulate gene expression. However, evidence suggests that BET...

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Detalles Bibliográficos
Autores principales: Barrows, John K., Lin, Baicheng, Quaas, Colleen E., Fullbright, George, Wallace, Elizabeth N., Long, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156784/
https://www.ncbi.nlm.nih.gov/pubmed/35641523
http://dx.doi.org/10.1038/s41467-022-30787-6