Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates

Biomolecular condensation of the neuronal microtubule‐associated protein Tau (MAPT) can be induced by coacervation with polyanions like RNA, or by molecular crowding. Tau condensates have been linked to both functional microtubule binding and pathological aggregation in neurodegenerative diseases. W...

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Detalles Bibliográficos
Autores principales: Hochmair, Janine, Exner, Christian, Franck, Maximilian, Dominguez‐Baquero, Alvaro, Diez, Lisa, Brognaro, Hévila, Kraushar, Matthew L, Mielke, Thorsten, Radbruch, Helena, Kaniyappan, Senthilvelrajan, Falke, Sven, Mandelkow, Eckhard, Betzel, Christian, Wegmann, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156969/
https://www.ncbi.nlm.nih.gov/pubmed/35298090
http://dx.doi.org/10.15252/embj.2021108882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156969/
https://www.ncbi.nlm.nih.gov/pubmed/35298090
http://dx.doi.org/10.15252/embj.2021108882

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