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Molecular crowding and RNA synergize to promote phase separation, microtubule interaction, and seeding of Tau condensates
Biomolecular condensation of the neuronal microtubule‐associated protein Tau (MAPT) can be induced by coacervation with polyanions like RNA, or by molecular crowding. Tau condensates have been linked to both functional microtubule binding and pathological aggregation in neurodegenerative diseases. W...
Autores principales: | Hochmair, Janine, Exner, Christian, Franck, Maximilian, Dominguez‐Baquero, Alvaro, Diez, Lisa, Brognaro, Hévila, Kraushar, Matthew L, Mielke, Thorsten, Radbruch, Helena, Kaniyappan, Senthilvelrajan, Falke, Sven, Mandelkow, Eckhard, Betzel, Christian, Wegmann, Susanne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156969/ https://www.ncbi.nlm.nih.gov/pubmed/35298090 http://dx.doi.org/10.15252/embj.2021108882 |
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