Cargando…

C‐terminal deletion‐induced condensation sequesters AID from IgH targets in immunodeficiency

In activated B cells, activation‐induced cytidine deaminase (AID) generates programmed DNA lesions required for antibody class switch recombination (CSR), which may also threaten genome integrity. AID dynamically shuttles between cytoplasm and nucleus, and the majority stays in the cytoplasm due to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Xia, Gan, Tingting, Rao, Bing, Zhang, Weiwei, Panchakshari, Rohit A, Yang, Dingpeng, Ji, Xiong, Cao, Yu, Alt, Frederick W, Meng, Fei‐Long, Hu, Jiazhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156971/ https://www.ncbi.nlm.nih.gov/pubmed/35471583 http://dx.doi.org/10.15252/embj.2021109324

Ejemplares similares

Long-range Oncogenic Activation of IgH/c-myc Translocations by the IgH 3’ Regulatory Region
por: Gostissa, Monica, et al.
Publicado: (2009)

Physiological role of the 3′IgH CBEs super-anchor in antibody class switching
por: Zhang, Xuefei, et al.
Publicado: (2021)

Analysis of Mice Lacking DNaseI Hypersensitive Sites at the 5′ End of the IgH Locus
por: Perlot, Thomas, et al.
Publicado: (2010)

Misregulation of the IgH Locus in Thymocytes
por: Kumari, Gita, et al.
Publicado: (2018)

Elucidation of the enigmatic IgD class-switch recombination via germline deletion of the IgH 3′ regulatory region
por: Rouaud, Pauline, et al.
Publicado: (2014)

Loop Extrusion Mediates Physiological IgH Locus Contraction For RAG Scanning
por: Dai, Hai-Qiang, et al.
Publicado: (2021)

Submicroscopic Deletions of Immunoglobulin Heavy Chain Gene (IGH) in Precursor B Lymphoblastic Leukemia with IGH Rearrangements
por: Huh, Jungwon, et al.
Publicado: (2015)

A role for AID in chromosome translocations between c-myc and the IgH variable region
por: Dorsett, Yair, et al.
Publicado: (2007)

A role for AID in chromosome translocations between c-myc and the IgH variable region
por: Dorsett, Yair, et al.
Publicado: (2007)

Individual Substitution Mutations in the AID C Terminus That Ablate IgH Class Switch Recombination
por: Kadungure, Tatenda, et al.
Publicado: (2015)

Synapsin condensation controls synaptic vesicle sequestering and dynamics
por: Hoffmann, Christian, et al.
Publicado: (2023)

Concentrating and sequestering biomolecules in condensates: impact on plant biology
por: Mountourakis, Fanourios, et al.
Publicado: (2022)

The IgH locus 3′ cis-regulatory super-enhancer co-opts AID for allelic transvection
por: Le Noir, Sandrine, et al.
Publicado: (2017)

Contribution of the IGCR1 regulatory element and the 3′Igh CTCF-binding elements to regulation of Igh V(D)J recombination
por: Liang, Zhuoyi, et al.
Publicado: (2023)

Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching
por: Dong, Junchao, et al.
Publicado: (2015)

The IgH 3′ regulatory region influences lymphomagenesis in Igλ-Myc mice
por: Saad, Faten, et al.
Publicado: (2015)

IgH Diversity In an Individual With Only One Million B Lymphocytes
por: Lee, Ada, et al.
Publicado: (1993)

Evolution of duplicated IgH loci in Atlantic salmon, Salmo salar
por: Yasuike, Motoshige, et al.
Publicado: (2010)

Nucleolar tethering mediates pairing between the IgH and Myc loci
por: Strongin, Daniel E, et al.
Publicado: (2014)

Three IgH isotypes, IgM, IgA and IgY are expressed in Gentoo penguin and zebra finch
por: Han, Binyue, et al.
Publicado: (2017)

UnAIDed Class Switching in Activated B-Cells Reveals Intrinsic Features of a Self-Cleaving IgH Locus
por: Dalloul, Iman, et al.
Publicado: (2021)

IgH gene rearrangements as plasma biomarkers in Non-Hodgkin's Lymphoma patients
por: He, Jian, et al.
Publicado: (2011)

IgH 3’ regulatory region increases ectopic class switch recombination
por: Le Noir, Sandrine, et al.
Publicado: (2021)

A role for the IgH intronic enhancer Eμ in enforcing allelic exclusion
por: Li, Fubin, et al.
Publicado: (2009)

The IgH 3’ regulatory region and c-myc-induced B-cell lymphomagenesis
por: Ghazzaui, Nour, et al.
Publicado: (2016)

Altered 3D chromatin structure permits inversional recombination at the IgH locus
por: Qiu, Xiang, et al.
Publicado: (2020)

Different B cell subpopulations show distinct patterns in their IgH repertoire metrics
por: Ghraichy, Marie, et al.
Publicado: (2021)

Dutcher bodies in an IgA‐myeloma patient harbouring the FGFR3/IGH fusion
por: Manabe, Masahiro, et al.
Publicado: (2023)

Critical roles of the immunoglobulin intronic enhancers in maintaining the sequential rearrangement of IgH and Igk loci
por: Inlay, Matthew A., et al.
Publicado: (2006)

Novel rearrangements at the immunoglobulin D locus. Inversions and fusions add to IgH somatic diversity
Publicado: (1989)

The IgH 3′ regulatory region controls somatic hypermutation in germinal center B cells
por: Rouaud, Pauline, et al.
Publicado: (2013)

A structural hierarchy mediated by multiple nuclear factors establishes IgH locus conformation
por: Gerasimova, Tatiana, et al.
Publicado: (2015)

Inter- and intratumoral heterogeneity of BCL2 correlates with IgH expression and prognosis in follicular lymphoma
por: Barreca, A, et al.
Publicado: (2014)

Double-Hit Primary Plasma Cell Leukemia with IGH/MYC and IGH/CCND1 Translocations
por: Yasumi, Masato, et al.
Publicado: (2020)

Extranodal marginal zone lymphoma of the dura mater with IgH/MALT1 translocation and review of literature
por: Bhagavathi, Sharathkumar, et al.
Publicado: (2008)

Distinct mechanisms define murine B cell lineage immunoglobulin heavy chain (IgH) repertoires
por: Yang, Yang, et al.
Publicado: (2015)

Efficient role of IgH 3′ regulatory region deficient B-cells in the development of oil granulomas
por: Ghazzaui, Nour, et al.
Publicado: (2016)

CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination
por: Marina-Zárate, Ester, et al.
Publicado: (2017)

Igh Locus Polymorphism May Dictate Topological Chromatin Conformation and V Gene Usage in the Ig Repertoire
por: Kenter, Amy L., et al.
Publicado: (2021)

Functional associations between polymorphic regions of the human 3'IgH locus and COVID-19 disease
por: Colucci, Mattia, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_fvj49if96hvti4crs7a1q6g00t