C‐terminal deletion‐induced condensation sequesters AID from IgH targets in immunodeficiency

In activated B cells, activation‐induced cytidine deaminase (AID) generates programmed DNA lesions required for antibody class switch recombination (CSR), which may also threaten genome integrity. AID dynamically shuttles between cytoplasm and nucleus, and the majority stays in the cytoplasm due to...

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Detalles Bibliográficos
Autores principales: Xie, Xia, Gan, Tingting, Rao, Bing, Zhang, Weiwei, Panchakshari, Rohit A, Yang, Dingpeng, Ji, Xiong, Cao, Yu, Alt, Frederick W, Meng, Fei‐Long, Hu, Jiazhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156971/
https://www.ncbi.nlm.nih.gov/pubmed/35471583
http://dx.doi.org/10.15252/embj.2021109324