Phase I study of PT-112, a novel pyrophosphate-platinum immunogenic cell death inducer, in advanced solid tumours

BACKGROUND: PT-112, the first pyrophosphate-platinum conjugate, causes immunogenic cell death in experimental models, leading to recruitment of tumour-infiltrating lymphocytes. PT-112 also associates with bone (osteotropism), likely driven by its pyrophosphate moiety. This is the first-in-human stud...

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Detalles Bibliográficos
Autores principales: Karp, Daniel D., Camidge, D. Ross, Infante, Jeffery R., Ames, Tyler D., Price, Matthew R., Jimeno, José, Bryce, Alan H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156977/
https://www.ncbi.nlm.nih.gov/pubmed/35747193
http://dx.doi.org/10.1016/j.eclinm.2022.101430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9156977/
https://www.ncbi.nlm.nih.gov/pubmed/35747193
http://dx.doi.org/10.1016/j.eclinm.2022.101430

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