A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially be used to modify or suppress pest populations, such as mosquitoes that spread diseases. CRISPR/Cas9 homing drives, which copy themselves by homology-d...

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Detalles Bibliográficos
Autores principales: Yang, Emily, Metzloff, Matthew, Langmüller, Anna M, Xu, Xuejiao, Clark, Andrew G, Messer, Philipp W, Champer, Jackson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157102/
https://www.ncbi.nlm.nih.gov/pubmed/35394026
http://dx.doi.org/10.1093/g3journal/jkac081

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157102/
https://www.ncbi.nlm.nih.gov/pubmed/35394026
http://dx.doi.org/10.1093/g3journal/jkac081

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