Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons

Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance seem to be quite complex, with suggestions in...

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Detalles Bibliográficos
Autores principales: Ohashi, Yusuke, Sakhri, Fatma Zahra, Ikemoto, Hideshi, Okumo, Takayuki, Adachi, Naoki, Sunagawa, Masataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157577/
https://www.ncbi.nlm.nih.gov/pubmed/35662731
http://dx.doi.org/10.3389/fphar.2022.862539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157577/
https://www.ncbi.nlm.nih.gov/pubmed/35662731
http://dx.doi.org/10.3389/fphar.2022.862539

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