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Yokukansan Inhibits the Development of Morphine Tolerance by Regulating Presynaptic Proteins in DRG Neurons
Opioids, such as morphine, are used in clinical settings for the management of acute and chronic pain. However, long-term use of morphine leads to antinociceptive tolerance and hypersensitivity. The cellular and molecular mechanisms of morphine tolerance seem to be quite complex, with suggestions in...
Autores principales: | Ohashi, Yusuke, Sakhri, Fatma Zahra, Ikemoto, Hideshi, Okumo, Takayuki, Adachi, Naoki, Sunagawa, Masataka |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157577/ https://www.ncbi.nlm.nih.gov/pubmed/35662731 http://dx.doi.org/10.3389/fphar.2022.862539 |
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