Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem

Synaptic dysfunction is a primary mechanism underlying Huntington disease (HD) progression. This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by means of (11)C-UCB-J small-animal PET imaging in the central nervous system of mice with HD. Methods: Dynamic (11)C-UCB-J...

Descripción completa

Detalles Bibliográficos
Autores principales: Bertoglio, Daniele, Verhaeghe, Jeroen, Wyffels, Leonie, Miranda, Alan, Stroobants, Sigrid, Mrzljak, Ladislav, Dominguez, Celia, Skinbjerg, Mette, Bard, Jonathan, Liu, Longbin, Munoz-Sanjuan, Ignacio, Staelens, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Nuclear Medicine 2022
Materias:
Basic (Molecular Imaging: Animal Imaging)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157723/
https://www.ncbi.nlm.nih.gov/pubmed/34531262
http://dx.doi.org/10.2967/jnumed.121.262709

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157723/
https://www.ncbi.nlm.nih.gov/pubmed/34531262
http://dx.doi.org/10.2967/jnumed.121.262709

Ejemplares similares