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Synaptic Vesicle Glycoprotein 2A Is Affected in the Central Nervous System of Mice with Huntington Disease and in the Brain of a Human with Huntington Disease Postmortem
Synaptic dysfunction is a primary mechanism underlying Huntington disease (HD) progression. This study investigated changes in synaptic vesicle glycoprotein 2A (SV2A) density by means of (11)C-UCB-J small-animal PET imaging in the central nervous system of mice with HD. Methods: Dynamic (11)C-UCB-J...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Society of Nuclear Medicine
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157723/ https://www.ncbi.nlm.nih.gov/pubmed/34531262 http://dx.doi.org/10.2967/jnumed.121.262709 |