Cargando…

Synthesis, Preclinical Evaluation, and a Pilot Clinical PET Imaging Study of (68)Ga-Labeled FAPI Dimer

Cancer-associated fibroblasts (CAFs) are crucial components of the tumor microenvironment. Fibroblast activation protein (FAP) is overexpressed in CAFs. FAP-targeted molecular imaging agents, including the FAP inhibitors (FAPIs) 04 and 46, have shown promising results in tumor diagnosis. However, th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Liang, Niu, Bo, Fang, Jianyang, Pang, Yizhen, Li, Siyang, Xie, Chengrong, Sun, Long, Zhang, Xianzhong, Guo, Zhide, Lin, Qin, Chen, Haojun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society of Nuclear Medicine 2022
Materias:	Basic Science Investigation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9157726/ https://www.ncbi.nlm.nih.gov/pubmed/34556528 http://dx.doi.org/10.2967/jnumed.121.263016

Ejemplares similares

Development of FAPI Tetramers to Improve Tumor Uptake and Efficacy of FAPI Radioligand Therapy
por: Pang, Yizhen, et al.
Publicado: (2023)

Synthesis, preclinical evaluation and radiation dosimetry of a dual targeting PET tracer [(68)Ga]Ga-FAPI-RGD
por: Zang, Jie, et al.
Publicado: (2022)

Clinical Evaluation of (68)Ga-FAPI-RGD for Imaging of Fibroblast Activation Protein and Integrin α(v)β(3) in Various Cancer Types
por: Zhao, Liang, et al.
Publicado: (2023)

Localization of Pyelonephritis by (68)Ga-FAPI PET CT
por: Jagtap, Rajlaxmi Rangrao, et al.
Publicado: (2023)

Pneumonia with Intense (68)Ga-FAPI Uptake Mimicking Metastasis on (68)Ga-FAPI PET/CT in a Patient with Rectal Cancer
por: Erol Fenercioğlu, Özge, et al.
Publicado: (2023)

(68)Ga-Labeled Maleimide for Blood Pool and Lymph PET Imaging through Covalent Bonding to Serum Albumin In Vivo
por: Feng, Lixia, et al.
Publicado: (2022)

Impact of (68)Ga-FAPI PET/CT on Staging and Oncologic Management in a Cohort of 226 Patients with Various Cancers
por: Koerber, Stefan A., et al.
Publicado: (2023)

Preclinical and exploratory human studies of novel (68)Ga-labeled D-peptide antagonist for PET imaging of TIGIT expression in cancers
por: Wang, Xiaobo, et al.
Publicado: (2022)

(68)Ga-FAPI-PET/CT in patients with various gynecological malignancies
por: Dendl, Katharina, et al.
Publicado: (2021)

Performance and Prospects of [(68)Ga]Ga-FAPI PET/CT Scans in Lung Cancer
por: Borgonje, Paula E., et al.
Publicado: (2022)

FAPI-04 Uptake in Healthy Tissues of Cancer Patients in (68)Ga-FAPI-04 PET/CT Imaging
por: Gündoğan, Cihan, et al.
Publicado: (2021)

Dynamic PET/CT Imaging of (68)Ga-FAPI-04 in Chinese Subjects
por: Wang, Shuailiang, et al.
Publicado: (2021)

(68)Ga-FAPI-04 PET/CT Findings in Patients with Liver Cirrhosis
por: Tatar, Gamze, et al.
Publicado: (2023)

(68)Ga- or (18)F-FAPI PET/CT—what it can and cannot
por: Mori, Yuriko, et al.
Publicado: (2023)

Superior Tumor Detection for (68)Ga-FAPI-46 Versus (18)F-FDG PET/CT and Conventional CT in Patients with Cholangiocarcinoma
por: Pabst, Kim M., et al.
Publicado: (2023)

Non-tumoral uptake of (68)Ga-FAPI-04 PET: A retrospective study
por: Qi, Na, et al.
Publicado: (2022)

In Vivo Fibroblast Activation of Systemic Sarcoidosis: A (68)Ga-FAPI-04 PET/CT Imaging Study
por: Wang, Jingnan, et al.
Publicado: (2023)

Radiosynthesis and First Preclinical Evaluation of the Novel (11)C-Labeled FAP Inhibitor (11)C-FAPI: A Comparative Study of (11)C-FAPIs and ((68)Ga) Ga-DOTA-FAPI-04 in a High–FAP-Expression Mouse Model
por: Wang, Cheng, et al.
Publicado: (2022)

Assessment of myocardial fibrosis in patients with systemic sclerosis using [(68)Ga]Ga-FAPI-04-PET-CT
por: Treutlein, Christoph, et al.
Publicado: (2022)

Cyclic (68)Ga-Labeled Peptides for Specific Detection of Human Angiotensin-Converting Enzyme 2
por: Parker, Matthew F.L., et al.
Publicado: (2021)

Correlation of (68)Ga-FAPi-46 PET Biodistribution with FAP Expression by Immunohistochemistry in Patients with Solid Cancers: Interim Analysis of a Prospective Translational Exploratory Study
por: Mona, Christine E., et al.
Publicado: (2022)

Improved cancer detection in Waldeyer’s tonsillar ring by (68)Ga-FAPI PET/CT imaging
por: Serfling, S., et al.
Publicado: (2020)

Early Detection of Checkpoint Inhibitor-Associated Myocarditis Using (68)Ga-FAPI PET/CT
por: Finke, Daniel, et al.
Publicado: (2021)

Comparison of (18)F-FDG PET/CT and (68)Ga-FAPI in Spindle Cell Rhabdomyosarcoma
por: Shen, Zhihui, et al.
Publicado: (2023)

Repeatability of (68)Ga-PSMA-HBED-CC PET/CT–Derived Total Molecular Tumor Volume
por: Seifert, Robert, et al.
Publicado: (2022)

Fully-automated production of [(68)Ga]Ga-FAPI-46 for clinical application
por: Spreckelmeyer, Sarah, et al.
Publicado: (2020)

[(68) Ga]Ga-FAPI uptake correlates with the state of chronic kidney disease
por: Conen, Patrick, et al.
Publicado: (2022)

(68)Ga-FAPI-04 Versus (18)F-FDG PET/CT in the Detection of Hepatocellular Carcinoma
por: Wang, Hao, et al.
Publicado: (2021)

Visualization of thermal damage using (68) Ga-FAPI-PET/CT after pulmonary vein isolation
por: Kupusovic, Jana, et al.
Publicado: (2021)

Distinguishing Benign and Malignant Findings on [(68) Ga]-FAPI PET/CT Based on Quantitative SUV Measurements
por: Dabir, M., et al.
Publicado: (2022)

Comparison of [68Ga]-FAPI PET/CT and [18F]-FDG PET/CT in Multiple Myeloma: Clinical Experience
por: Elboga, Umut, et al.
Publicado: (2022)

Fully automated radiosynthesis of [(68)Ga]Ga-FAPI-46 with cyclotron produced gallium
por: Rosenberg, Adam J., et al.
Publicado: (2023)

Automated Synthesis of [(68)Ga]Ga-FAPI-46 on a Scintomics GRP Synthesizer
por: Plhak, Elisabeth, et al.
Publicado: (2023)

Ga68-FAPI Imaging and Lu177-FAPI Therapy in a Case of Metastatic Solitary Fibrous Tumor
por: Luthra, Karuna, et al.
Publicado: (2023)

Feasibility of [(68)Ga]Ga-FAPI-46 PET/CT for detection of nodal and hematogenous spread in high-grade urothelial carcinoma
por: Unterrainer, Lena M., et al.
Publicado: (2022)

Comparison of [(68)Ga]Ga-DOTA-FAPI-04 and [(18)F]FDG PET/MRI in the Preoperative Diagnosis of Gastric Cancer
por: Du, Tao, et al.
Publicado: (2023)

Dual targeting PET tracer [(68)Ga]Ga-FAPI-RGD in patients with lung neoplasms: a pilot exploratory study
por: Wang, Rongxi, et al.
Publicado: (2023)

The Application of [(68)Ga]-Labeled FAPI-04 PET/CT for Targeting and Early Detection of Pancreatic Carcinoma in Patient-Derived Orthotopic Xenograft Models
por: Zhang, He, et al.
Publicado: (2022)

Impact of (68)Ga-FAPI-04 PET/CT on Staging and Therapeutic Management in Patients With Digestive System Tumors
por: Kosmala, Aleksander, et al.
Publicado: (2023)

Comparison of (68)Ga-FAPI-04 and fluorine-18-fluorodeoxyglucose PET/computed tomography in the detection of ovarian malignancies
por: Zheng, Wenlu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5uign3appq19ec85ik3bgetnlr