Asymmetric addition of Grignard reagents to ketones: culmination of the ligand-mediated methodology allows modular construction of chiral tertiary alcohols

A new class of biaryl chiral ligands derived from 1,2-diaminocyclohexane (1,2-DACH) has been designed to enable the asymmetric addition of aliphatic and, for the first time, aromatic Grignard reagents to ketones for the preparation of highly enantioenriched tertiary alcohols (up to 95% ee). The newl...

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Detalles Bibliográficos
Autores principales: Monasterolo, Claudio, O'Gara, Ryan, Kavanagh, Saranna E., Byrne, Sadbh E., Bieszczad, Bartosz, Murray, Orla, Wiesinger, Michael, Lynch, Rebecca A., Nikitin, Kirill, Gilheany, Declan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159101/
https://www.ncbi.nlm.nih.gov/pubmed/35733895
http://dx.doi.org/10.1039/d1sc06350b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159101/
https://www.ncbi.nlm.nih.gov/pubmed/35733895
http://dx.doi.org/10.1039/d1sc06350b

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