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Astrocyte reactivity in a mouse model of SCN8A epileptic encephalopathy

OBJECTIVE: SCN8A epileptic encephalopathy is caused predominantly by de novo gain‐of‐function mutations in the voltage‐gated sodium channel Na(v)1.6. The disorder is characterized by early onset of seizures and developmental delay. Most patients with SCN8A epileptic encephalopathy are refractory to...

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Detalles Bibliográficos
Autores principales: Thompson, Jeremy A., Miralles, Raquel M., Wengert, Eric R., Wagley, Pravin K., Yu, Wenxi, Wenker, Ian C., Patel, Manoj K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159254/
https://www.ncbi.nlm.nih.gov/pubmed/34826216
http://dx.doi.org/10.1002/epi4.12564