α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?

The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes p...

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Autores principales: Brodin, Lennart, Milovanovic, Dragomir, Rizzoli, Silvio O., Shupliakov, Oleg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159372/
https://www.ncbi.nlm.nih.gov/pubmed/35664678
http://dx.doi.org/10.3389/fmolb.2022.891508
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author Brodin, Lennart
Milovanovic, Dragomir
Rizzoli, Silvio O.
Shupliakov, Oleg
author_facet Brodin, Lennart
Milovanovic, Dragomir
Rizzoli, Silvio O.
Shupliakov, Oleg
author_sort Brodin, Lennart
collection PubMed
description The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease.
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spelling pubmed-91593722022-06-02 α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander? Brodin, Lennart Milovanovic, Dragomir Rizzoli, Silvio O. Shupliakov, Oleg Front Mol Biosci Molecular Biosciences The protein α-synuclein, which is well-known for its links to Parkinson’s Disease, is associated with synaptic vesicles (SVs) in nerve terminals. Despite intensive studies, its precise physiological function remains elusive. Accumulating evidence indicates that liquid-liquid phase separation takes part in the assembly and/or maintenance of different synaptic compartments. The current review discusses recent data suggesting α-synuclein as a component of the SV liquid phase. We also consider possible implications of these data for disease. Frontiers Media S.A. 2022-05-18 /pmc/articles/PMC9159372/ /pubmed/35664678 http://dx.doi.org/10.3389/fmolb.2022.891508 Text en Copyright © 2022 Brodin, Milovanovic, Rizzoli and Shupliakov. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Brodin, Lennart
Milovanovic, Dragomir
Rizzoli, Silvio O.
Shupliakov, Oleg
α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
title α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
title_full α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
title_fullStr α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
title_full_unstemmed α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
title_short α-Synuclein in the Synaptic Vesicle Liquid Phase: Active Player or Passive Bystander?
title_sort α-synuclein in the synaptic vesicle liquid phase: active player or passive bystander?
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159372/
https://www.ncbi.nlm.nih.gov/pubmed/35664678
http://dx.doi.org/10.3389/fmolb.2022.891508
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