“Orphan” Connexin43 in Plakophilin-2 Deficient Hearts Revealed by Volume Electron Microscopy

Previous studies revealed an abundance of functional Connexin43 (Cx43) hemichannels consequent to loss of plakophilin-2 (PKP2) expression in adult murine hearts. The increased Cx43-mediated membrane permeability is likely responsible for excess entry of calcium into the cells, leading to an arrhythm...

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Detalles Bibliográficos
Autores principales: van Opbergen, Chantal J. M., Sall, Joseph, Petzold, Chris, Dancel-Manning, Kristen, Delmar, Mario, Liang, Feng-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159532/
https://www.ncbi.nlm.nih.gov/pubmed/35663385
http://dx.doi.org/10.3389/fcell.2022.843687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159532/
https://www.ncbi.nlm.nih.gov/pubmed/35663385
http://dx.doi.org/10.3389/fcell.2022.843687

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