Spatial interplay patterns of cancer nuclei and tumor-infiltrating lymphocytes (TILs) predict clinical benefit for immune checkpoint inhibitors

Immune checkpoint inhibitors (ICIs) show prominent clinical activity across multiple advanced tumors. However, less than half of patients respond even after molecule-based selection. Thus, improved biomarkers are required. In this study, we use an image analysis to capture morphologic attributes rel...

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Detalles Bibliográficos
Autores principales: Wang, Xiangxue, Barrera, Cristian, Bera, Kaustav, Viswanathan, Vidya Sankar, Azarianpour-Esfahani, Sepideh, Koyuncu, Can, Velu, Priya, Feldman, Michael D., Yang, Michael, Fu, Pingfu, Schalper, Kurt A., Mahdi, Haider, Lu, Cheng, Velcheti, Vamsidhar, Madabhushi, Anant
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159577/
https://www.ncbi.nlm.nih.gov/pubmed/35648850
http://dx.doi.org/10.1126/sciadv.abn3966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159577/
https://www.ncbi.nlm.nih.gov/pubmed/35648850
http://dx.doi.org/10.1126/sciadv.abn3966

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