Cargando…
Machine learning predicts translation initiation sites in neurologic diseases with nucleotide repeat expansions
A number of neurologic diseases associated with expanded nucleotide repeats, including an inherited form of amyotrophic lateral sclerosis, have an unconventional form of translation called repeat-associated non-AUG (RAN) translation. It has been speculated that the repeat regions in the RNA fold int...
Autores principales: | Gleason, Alec C., Ghadge, Ghanashyam, Chen, Jin, Sonobe, Yoshifumi, Roos, Raymond P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159584/ https://www.ncbi.nlm.nih.gov/pubmed/35648796 http://dx.doi.org/10.1371/journal.pone.0256411 |
Ejemplares similares
-
Kozak Similarity Score Algorithm Identifies Alternative Translation Initiation Codons Implicated in Cancers
por: Gleason, Alec C., et al.
Publicado: (2022) -
TDP-43 proteinopathy in Theiler’s murine encephalomyelitis virus
infection
por: Masaki, Katsuhisa, et al.
Publicado: (2019) -
Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons
por: Sonobe, Yoshifumi, et al.
Publicado: (2023) -
RNA-binding protein altered expression and mislocalization in MS
por: Masaki, Katsuhisa, et al.
Publicado: (2020) -
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
por: Sonobe, Yoshifumi, et al.
Publicado: (2021)