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DIRECT-NET: An efficient method to discover cis-regulatory elements and construct regulatory networks from single-cell multiomics data

The emergence of single-cell multiomics data provides unprecedented opportunities to scrutinize the transcriptional regulatory mechanisms controlling cell identity. However, how to use those datasets to dissect the cis-regulatory element (CRE)–to–gene relationships at a single-cell level remains a m...

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Detalles Bibliográficos
Autores principales: Zhang, Lihua, Zhang, Jing, Nie, Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159696/
https://www.ncbi.nlm.nih.gov/pubmed/35648859
http://dx.doi.org/10.1126/sciadv.abl7393