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Intestinal Barrier Dysfunction in the Absence of Systemic Inflammation Fails to Exacerbate Motor Dysfunction and Brain Pathology in a Mouse Model of Parkinson's Disease

INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disease associated with aging. PD patients have systemic and neuroinflammation which is hypothesized to contribute to neurodegeneration. Recent studies highlight the importance of the gut-brain axis in PD pathoge...

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Detalles Bibliográficos
Autores principales: Jackson, Aeja, Engen, Phillip A., Forsyth, Christopher B., Shaikh, Maliha, Naqib, Ankur, Wilber, Sherry, Frausto, Dulce M., Raeisi, Shohreh, Green, Stefan J., Bradaric, Brinda Desai, Persons, Amanda L., Voigt, Robin M., Keshavarzian, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9159909/
https://www.ncbi.nlm.nih.gov/pubmed/35665034
http://dx.doi.org/10.3389/fneur.2022.882628