Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression

Activity-induced neurogenesis has been extensively studied in rodents but the lack of ante mortem accessibility to human brain at the cellular and molecular levels limits studies of the process in humans. Using cerebral spheroids derived from human induced pluripotent stem cells (iPSCs), we investig...

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Detalles Bibliográficos
Autores principales: Parmentier, Thomas, James, Fiona M. K., Hewitson, Elizabeth, Bailey, Craig, Werry, Nicholas, Sheridan, Steven D., Perlis, Roy H., Perreault, Melissa L., Gaitero, Luis, Lalonde, Jasmin, LaMarre, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160269/
https://www.ncbi.nlm.nih.gov/pubmed/35650420
http://dx.doi.org/10.1038/s41598-022-13071-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160269/
https://www.ncbi.nlm.nih.gov/pubmed/35650420
http://dx.doi.org/10.1038/s41598-022-13071-x

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