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Human cerebral spheroids undergo 4-aminopyridine-induced, activity associated changes in cellular composition and microrna expression
Activity-induced neurogenesis has been extensively studied in rodents but the lack of ante mortem accessibility to human brain at the cellular and molecular levels limits studies of the process in humans. Using cerebral spheroids derived from human induced pluripotent stem cells (iPSCs), we investig...
Autores principales: | Parmentier, Thomas, James, Fiona M. K., Hewitson, Elizabeth, Bailey, Craig, Werry, Nicholas, Sheridan, Steven D., Perlis, Roy H., Perreault, Melissa L., Gaitero, Luis, Lalonde, Jasmin, LaMarre, Jonathan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160269/ https://www.ncbi.nlm.nih.gov/pubmed/35650420 http://dx.doi.org/10.1038/s41598-022-13071-x |
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