Omeprazole Treatment Failure in Gastroesophageal Reflux Disease and Genetic Variation at the CYP2C Locus

Omeprazole is extensively used to manage gastroesophageal reflux disease (GERD). It is primarily metabolized by CYP2C19. The CYP2C19*17 (rs12248560) allele and the recently described CYP2C:TG haplotype (rs11188059 and rs2860840) are associated with increased enzymatic activity, and may reduce omepra...

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Detalles Bibliográficos
Autores principales: Kee, Ping Siu, Maggo, Simran D. S., Kennedy, Martin A., Barclay, Murray L., Miller, Allison L., Lehnert, Klaus, Curtis, Maurice A., Faull, Richard L. M., Parker, Remai, Chin, Paul K. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160307/
https://www.ncbi.nlm.nih.gov/pubmed/35664313
http://dx.doi.org/10.3389/fgene.2022.869160

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160307/
https://www.ncbi.nlm.nih.gov/pubmed/35664313
http://dx.doi.org/10.3389/fgene.2022.869160

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