Nanomechanics combined with HDX reveals allosteric drug binding sites of CFTR NBD1

Cystic fibrosis (CF) is a frequent genetic disease in Caucasians that is caused by the deletion of F508 (ΔF508) in the nucleotide binding domain 1 (NBD1) of the CF transmembrane conductance regulator (CFTR). The ΔF508 compromises the folding energetics of the NBD1, as well as the folding of three ot...

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Detalles Bibliográficos
Autores principales: Padányi, Rita, Farkas, Bianka, Tordai, Hedvig, Kiss, Bálint, Grubmüller, Helmut, Soya, Naoto, Lukács, Gergely L., Kellermayer, Miklós, Hegedűs, Tamás
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160490/
https://www.ncbi.nlm.nih.gov/pubmed/35685375
http://dx.doi.org/10.1016/j.csbj.2022.05.036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160490/
https://www.ncbi.nlm.nih.gov/pubmed/35685375
http://dx.doi.org/10.1016/j.csbj.2022.05.036

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