Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs

Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to improve the solubility and bioavailability of RIV. Five cocrystals—p-hydroxybenzoic acid (HBA), 2,4-dihydro...

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Detalles Bibliográficos
Autores principales: Meng, Yuanyuan, Tan, Fangyun, Yao, Jiaxin, Cui, Yanan, Feng, Yumiao, Li, Zhiping, Wang, Yuli, Yang, Yang, Gong, Wei, Yang, Meiyan, Kong, Xiaolong, Gao, Chunsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160491/
https://www.ncbi.nlm.nih.gov/pubmed/35663355
http://dx.doi.org/10.1016/j.ijpx.2022.100119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160491/
https://www.ncbi.nlm.nih.gov/pubmed/35663355
http://dx.doi.org/10.1016/j.ijpx.2022.100119

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