Cargando…

Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs

Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to improve the solubility and bioavailability of RIV. Five cocrystals—p-hydroxybenzoic acid (HBA), 2,4-dihydro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Meng, Yuanyuan, Tan, Fangyun, Yao, Jiaxin, Cui, Yanan, Feng, Yumiao, Li, Zhiping, Wang, Yuli, Yang, Yang, Gong, Wei, Yang, Meiyan, Kong, Xiaolong, Gao, Chunsheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160491/ https://www.ncbi.nlm.nih.gov/pubmed/35663355 http://dx.doi.org/10.1016/j.ijpx.2022.100119

Ejemplares similares

Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals
por: Feng, Yumiao, et al.
Publicado: (2021)

Improved Manufacturability and In Vivo Comparative Pharmacokinetics of Dapagliflozin Cocrystals in Beagle Dogs and Human Volunteers
por: Cho, Sangho, et al.
Publicado: (2021)

Preparation and pharmacokinetics in beagle dogs of ganershu sustained-release pellets
por: Pan, Jin-huo, et al.
Publicado: (2014)

Effect of Itraconazole on the Pharmacokinetics of Diclofenac in Beagle Dogs
por: Al-Jenoobi, Fahad I.
Publicado: (2010)

Pharmacokinetics and Pharmacodynamics of Immediate- and Modified-Release Mycophenolic Acid Preparations in Healthy Beagle Dogs
por: Klotsman, Michael, et al.
Publicado: (2021)

Pharmacokinetics of BMEDA after Intravenous Administration in Beagle Dogs
por: Chang, Chih-Hsien, et al.
Publicado: (2014)

In vitro/vivo assessment of praziquantel nanocrystals: Formulation, characterization, and pharmacokinetics in beagle dogs
por: Yang, Ruyi, et al.
Publicado: (2019)

Pharmacokinetic Studies of Sustained-Release Depot of Dexamethasone in Beagle Dogs
por: Blizzard, Charles, et al.
Publicado: (2016)

Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation
por: Lu, Zhongyu, et al.
Publicado: (2023)

Pharmacokinetics of propafenone hydrochloride sustained-release capsules in male beagle dogs
por: Pan, Liping, et al.
Publicado: (2015)

Red blood cell-hitchhiking mediated pulmonary delivery of ivermectin: Effects of nanoparticle properties
por: Zheng, Jinpeng, et al.
Publicado: (2022)

Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
por: Zhang, Hao, et al.
Publicado: (2017)

Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs
por: Yang, Hyuck-Joo, et al.
Publicado: (2018)

Recent Advances in Strategies to Combat Bacterial Drug Resistance: Antimicrobial Materials and Drug Delivery Systems
por: Yao, Jiaxin, et al.
Publicado: (2023)

Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration
por: Zhang, Yuqiao, et al.
Publicado: (2016)

Ocular Distribution and Pharmacokinetics of Lifitegrast in Pigmented Rabbits and Mass Balance in Beagle Dogs
por: Chung, Jou-Ku, et al.
Publicado: (2018)

The Effect of Posaconazole and Isavuconazole on the Pharmacokinetics of Erdafitinib in Beagle Dogs by UPLC-MS/MS
por: Ruan, Lan-hong, et al.
Publicado: (2021)

A novel preparative method for nanoparticle albumin-bound paclitaxel with high drug loading and its evaluation both in vitro and in vivo
por: Gao, Yue, et al.
Publicado: (2021)

Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells
por: Nai, Jingxue, et al.
Publicado: (2021)

Pharmacokinetics and Novel Metabolite Identification of Tartary Buckwheat Extracts in Beagle Dogs Following Co-Administration with Ethanol
por: Liu, Yuancai, et al.
Publicado: (2019)

Penis Allotransplantation in Beagle Dog
por: Zhao, Yongbin, et al.
Publicado: (2016)

Preparation and physicochemical characterization of sildenafil cocrystals
por: Sawatdee, Somchai, et al.
Publicado: (2021)

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique
por: Wang, Hui-jun, et al.
Publicado: (2021)

Determination of Tropifexor in Beagle Dog Plasma by UPLC-MS/MS and Its Application in Pharmacokinetics
por: Su, Yan-Ding, et al.
Publicado: (2022)

Comparison of fecal microbiota of SPF and non-SPF Beagle dogs
por: Yu, Cuilian, et al.
Publicado: (2023)

Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids
por: Yu, Hongmei, et al.
Publicado: (2022)

Crystal Structure, Solubility, and Pharmacokinetic Study on a Hesperetin Cocrystal with Piperine as Coformer
por: Liu, Yanjie, et al.
Publicado: (2022)

Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles
por: Levionnois, Olivier Louis, et al.
Publicado: (2022)

Microcirculation changes in gingival tissue after ultrasonic tooth preparation in beagle dogs
por: TO, Masahiro, et al.
Publicado: (2020)

Effects of ticagrelor on the pharmacokinetics of rivaroxaban in rats
por: Chong, Jia, et al.
Publicado: (2020)

Recent Advances in Pharmaceutical Cocrystals: A Focused Review of Flavonoid Cocrystals
por: Xu, Jia, et al.
Publicado: (2023)

Lung-Targeted Delivery of Cepharanthine by an Erythrocyte-Anchoring Strategy for the Treatment of Acute Lung Injury
por: Zheng, Jinpeng, et al.
Publicado: (2022)

A New Model to Describe the Single-dose Pharmacokinetics of Bevacizumab and Predict Its Multiple-Dose Pharmacokinetics in Beagle Dogs
por: Li, Meizhen, et al.
Publicado: (2019)

Gut Microbiota-Regulated Pharmacokinetics of Berberine and Active Metabolites in Beagle Dogs After Oral Administration
por: Feng, Ru, et al.
Publicado: (2018)

Pharmacokinetic Modeling of Ceftiofur Sodium Using Non-linear Mixed-Effects in Healthy Beagle Dogs
por: Wang, Jianzhong, et al.
Publicado: (2019)

Pharmacokinetics of intravenous administered two different high doses of ascorbic acid in healthy beagle dogs
por: Lim, Seula, et al.
Publicado: (2019)

Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies
por: Xiong, Wei, et al.
Publicado: (2021)

Rapid Colloidal Gold Immunoassay for Pharmacokinetic Evaluation of Vancomycin in the Cerebrospinal Fluid and Plasma of Beagle Dogs
por: Guo, Yechang, et al.
Publicado: (2023)

The Pharmacokinetic Effect of Itraconazole and Voriconazole on Ripretinib in Beagle Dogs by UPLC-MS/MS Technique [Corrigendum]
Publicado: (2023)

Evaluation of Marbofloxacin in Beagle Dogs After Oral Dosing: Preclinical Safety Evaluation and Comparative Pharmacokinetics of Two Different Tablets
por: Lei, Zhixin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_8msbqavg1p9028qcti4uu0grp1