Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region

AA amyloidosis is the result of overproduction and aberrant processing of acute-phase serum amyloid A1 (SAA1) by hepatocytes. Proteolytic cleavage of SAA1 is believed to play a central role in AA amyloid formation. The SAA1 protein undergoes a cleavage of 18 residues consisting of the signal peptide...

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Detalles Bibliográficos
Autores principales: Haines, Morgan S., Ramirez, Eduardo, Moore, Kendall B.E., Fortin, Jessica S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160670/
https://www.ncbi.nlm.nih.gov/pubmed/35664543
http://dx.doi.org/10.1016/j.bbrep.2022.101284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160670/
https://www.ncbi.nlm.nih.gov/pubmed/35664543
http://dx.doi.org/10.1016/j.bbrep.2022.101284

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