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Revisiting misfolding propensity of serum amyloid A1: Special focus on the signal peptide region
AA amyloidosis is the result of overproduction and aberrant processing of acute-phase serum amyloid A1 (SAA1) by hepatocytes. Proteolytic cleavage of SAA1 is believed to play a central role in AA amyloid formation. The SAA1 protein undergoes a cleavage of 18 residues consisting of the signal peptide...
Autores principales: | Haines, Morgan S., Ramirez, Eduardo, Moore, Kendall B.E., Fortin, Jessica S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9160670/ https://www.ncbi.nlm.nih.gov/pubmed/35664543 http://dx.doi.org/10.1016/j.bbrep.2022.101284 |
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