Homologous recombination deficiency is inversely correlated with microsatellite instability and identifies immunologically cold tumors in most cancer types

Homologous recombination deficiency (HRD) leads to DNA double‐strand breaks and can be exploited by the use of poly (ADP‐ribose) polymerase (PARP) inhibitors to induce synthetic lethality. Extending the original therapeutic concept, the role of HRD is currently being investigated in clinical trials...

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Detalles Bibliográficos
Autores principales: Budczies, Jan, Kluck, Klaus, Beck, Susanne, Ourailidis, Iordanis, Allgäuer, Michael, Menzel, Michael, Kazdal, Daniel, Perkhofer, Lukas, Kleger, Alexander, Schirmacher, Peter, Seufferlein, Thomas, Stenzinger, Albrecht
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161338/
https://www.ncbi.nlm.nih.gov/pubmed/35384413
http://dx.doi.org/10.1002/cjp2.271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161338/
https://www.ncbi.nlm.nih.gov/pubmed/35384413
http://dx.doi.org/10.1002/cjp2.271

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