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Impaired dynamic interaction of axonal endoplasmic reticulum and ribosomes contributes to defective stimulus–response in spinal muscular atrophy

BACKGROUND: Axonal degeneration and defects in neuromuscular neurotransmission represent a pathological hallmark in spinal muscular atrophy (SMA) and other forms of motoneuron disease. These pathological changes do not only base on altered axonal and presynaptic architecture, but also on alterations...

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Detalles Bibliográficos
Autores principales: Deng, Chunchu, Reinhard, Sebastian, Hennlein, Luisa, Eilts, Janna, Sachs, Stefan, Doose, Sören, Jablonka, Sibylle, Sauer, Markus, Moradi, Mehri, Sendtner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161492/
https://www.ncbi.nlm.nih.gov/pubmed/35650592
http://dx.doi.org/10.1186/s40035-022-00304-2