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Inhibition of Serine Proteases as a Novel Therapeutic Strategy for Abdominal Pain in IBS

Serine proteases are heavily present in the gastrointestinal tract where they are essential in numerous physiological processes. An imbalance in the proteolytic activity is a central mechanism underlying abdominal pain in irritable bowel syndrome (IBS). Therefore, protease inhibitors are emerging as...

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Detalles Bibliográficos
Autores principales: Decraecker, Lisse, Boeckxstaens, Guy, Denadai-Souza, Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9161638/
https://www.ncbi.nlm.nih.gov/pubmed/35665224
http://dx.doi.org/10.3389/fphys.2022.880422