An immuno-enrichment free, validated quantification of tau protein in human CSF by LC-MS/MS

Tau protein is a key target of interest in developing therapeutics for neurodegenerative diseases. Here, we sought to develop a method that quantifies extracellular tau protein concentrations in human cerebrospinal fluid (CSF) without antibody-based enrichment strategies. We demonstrate that the fit...

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Detalles Bibliográficos
Autores principales: Self, Wade, Awwad, Khader, Savaryn, John Paul, Schulz, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162344/
https://www.ncbi.nlm.nih.gov/pubmed/35653415
http://dx.doi.org/10.1371/journal.pone.0269157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162344/
https://www.ncbi.nlm.nih.gov/pubmed/35653415
http://dx.doi.org/10.1371/journal.pone.0269157

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