Inhibition of miR-421 Preserves Mitochondrial Function and Protects against Parkinson's Disease Pathogenesis via Pink1/Parkin-Dependent Mitophagy

Mutations in PINK1 and Parkin are a major cause of Parkinson's disease (PD) pathogenesis. In addition, PINK1 and Parkin are two mitochondrial proteins that jointly contribute to mitochondrial homeostasis via mitophagy. Mitochondrial dysfunction is the most significant mechanism underlying PD pa...

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Detalles Bibliográficos
Autores principales: Dong, Xiaolin, He, Xianghua, Yang, Li, Li, Qingyun, Xu, Yanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162809/
https://www.ncbi.nlm.nih.gov/pubmed/35664430
http://dx.doi.org/10.1155/2022/5186252

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162809/
https://www.ncbi.nlm.nih.gov/pubmed/35664430
http://dx.doi.org/10.1155/2022/5186252

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