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Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization
Bone marrow mesenchymal stem cells (BMSCs) have been identified as a potential therapeutic approach to immune-related diseases. Here, we show that BMSC-derived exosomes promote FOXP3 expression and induce the conversion of CD4(+) T cells into CD4(+)CD25(+)FOXP3(+) Treg cells, which is significant fo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162841/ https://www.ncbi.nlm.nih.gov/pubmed/35664563 http://dx.doi.org/10.1155/2022/8890434 |
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author | Wang, Renyong Li, Ruixue Li, Tiehan Zhu, Lei Qi, Zongze Yang, Xiaokui Wang, Huan Cao, Baoquan Zhu, Hong |
author_facet | Wang, Renyong Li, Ruixue Li, Tiehan Zhu, Lei Qi, Zongze Yang, Xiaokui Wang, Huan Cao, Baoquan Zhu, Hong |
author_sort | Wang, Renyong |
collection | PubMed |
description | Bone marrow mesenchymal stem cells (BMSCs) have been identified as a potential therapeutic approach to immune-related diseases. Here, we show that BMSC-derived exosomes promote FOXP3 expression and induce the conversion of CD4(+) T cells into CD4(+)CD25(+)FOXP3(+) Treg cells, which is significant for immunosuppressive activity. We found that miR-181a-5p is upregulated in BMSC-derived exosomes and can be transferred to CD4(+) T cells. In CD4(+) cells, miR-181a directly targets SIRT1 and suppresses its expression. Moreover, downregulated SIRT1 enhances FOXP3 via protein acetylation. In conclusion, our data demonstrated that BMSC-derived exosomal miR-181a is critical in the maintenance of immune tolerance. Furthermore, our results reveal that BMSC-derived exosomal miR-181a induces the production of CD4(+)CD25(+)FOXP3(+) Treg cells via SIRT1/acetylation/FOXP3. |
format | Online Article Text |
id | pubmed-9162841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-91628412022-06-03 Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization Wang, Renyong Li, Ruixue Li, Tiehan Zhu, Lei Qi, Zongze Yang, Xiaokui Wang, Huan Cao, Baoquan Zhu, Hong J Oncol Research Article Bone marrow mesenchymal stem cells (BMSCs) have been identified as a potential therapeutic approach to immune-related diseases. Here, we show that BMSC-derived exosomes promote FOXP3 expression and induce the conversion of CD4(+) T cells into CD4(+)CD25(+)FOXP3(+) Treg cells, which is significant for immunosuppressive activity. We found that miR-181a-5p is upregulated in BMSC-derived exosomes and can be transferred to CD4(+) T cells. In CD4(+) cells, miR-181a directly targets SIRT1 and suppresses its expression. Moreover, downregulated SIRT1 enhances FOXP3 via protein acetylation. In conclusion, our data demonstrated that BMSC-derived exosomal miR-181a is critical in the maintenance of immune tolerance. Furthermore, our results reveal that BMSC-derived exosomal miR-181a induces the production of CD4(+)CD25(+)FOXP3(+) Treg cells via SIRT1/acetylation/FOXP3. Hindawi 2022-05-26 /pmc/articles/PMC9162841/ /pubmed/35664563 http://dx.doi.org/10.1155/2022/8890434 Text en Copyright © 2022 Renyong Wang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Wang, Renyong Li, Ruixue Li, Tiehan Zhu, Lei Qi, Zongze Yang, Xiaokui Wang, Huan Cao, Baoquan Zhu, Hong Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization |
title | Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization |
title_full | Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization |
title_fullStr | Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization |
title_full_unstemmed | Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization |
title_short | Bone Mesenchymal Stem Cell-Derived Exosome-Enclosed miR-181a Induces CD4(+)CD25(+)FOXP3(+) Regulatory T Cells via SIRT1/Acetylation-Mediated FOXP3 Stabilization |
title_sort | bone mesenchymal stem cell-derived exosome-enclosed mir-181a induces cd4(+)cd25(+)foxp3(+) regulatory t cells via sirt1/acetylation-mediated foxp3 stabilization |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162841/ https://www.ncbi.nlm.nih.gov/pubmed/35664563 http://dx.doi.org/10.1155/2022/8890434 |
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