High expression level of ROR1 and ROR1-signaling associates with venetoclax resistance in chronic lymphocytic leukemia

Although the BH3-mimetic venetoclax is highly cytotoxic for chronic lymphocytic leukemia (CLL) cells, some patients with CLL fail to clear minimal residual disease (MRD). We examined the CLL cells of seven such patients (CLL1-7) and found each had high-level expression of ROR1. By examining the CLL...

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Detalles Bibliográficos
Autores principales: Ghia, Emanuela M., Rassenti, Laura Z., Choi, Michael Y., Quijada-Álamo, Miguel, Chu, Elvin, Widhopf, George F., Kipps, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162914/
https://www.ncbi.nlm.nih.gov/pubmed/35418613
http://dx.doi.org/10.1038/s41375-022-01543-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162914/
https://www.ncbi.nlm.nih.gov/pubmed/35418613
http://dx.doi.org/10.1038/s41375-022-01543-y

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