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Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments

Gene silencing in bacteria is mediated by chromatin proteins, of which Escherichia coli H-NS is a paradigmatic example. H-NS forms nucleoprotein filaments with either one or two DNA duplexes. However, the structures, arrangements of DNA-binding domains (DBDs), and positions of DBD–DNA contacts in li...

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Detalles Bibliográficos
Autores principales: Shen, Beth A., Hustmyer, Christine M., Roston, Daniel, Wolfe, Michael B., Landick, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162952/
https://www.ncbi.nlm.nih.gov/pubmed/35669520
http://dx.doi.org/10.1016/j.isci.2022.104429