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Can we infer tumor presence of single cell transcriptomes and their tumor of origin from bulk transcriptomes by machine learning?
There is a growing need to build a model that uses single cell RNA-seq (scRNA-seq) to separate malignant cells from nonmalignant cells and to identify tumor of origin of single cells and/or circulating tumor cells (CTCs). Currently, it is infeasible to build a tumor of origin model learnt from scRNA...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9162953/ https://www.ncbi.nlm.nih.gov/pubmed/35685355 http://dx.doi.org/10.1016/j.csbj.2022.05.035 |