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Discovery of the cyclotide caripe 11 as a ligand of the cholecystokinin-2 receptor

The cholecystokinin-2 receptor (CCK(2)R) is a G protein-coupled receptor (GPCR) that is expressed in peripheral tissues and the central nervous system and constitutes a promising target for drug development in several diseases, such as gastrointestinal cancer. The search for ligands of this receptor...

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Detalles Bibliográficos
Autores principales: Taghizadeh, Mohammad Sadegh, Retzl, Bernhard, Muratspahić, Edin, Trenk, Christoph, Casanova, Emilio, Moghadam, Ali, Afsharifar, Alireza, Niazi, Ali, Gruber, Christian W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9163038/
https://www.ncbi.nlm.nih.gov/pubmed/35654807
http://dx.doi.org/10.1038/s41598-022-13142-z